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ea0037gp.15.05 | Diabetes and obesity – basic | ECE2015

Stable analogues of the dual agonist dogfish glucagon show better therapeutic potential than exendin-4 in diet induced obese diabetic mice

O'Harte Finbarr P M , Ng Ming T , Conlon J Michael , Flatt Peter R

Recent acute in vivo studies have shown that structural modifications of dogfish glucagon improves peptide stability and these analogues can act as dual agonists at both glucagon and GLP-1 receptors. Here, we compared the effects of chronic (51 days) twice daily administration of [D-Ala2]dogfish glucagon (Pep-N) and [D-Ala2]dogfish glucagon-exendin-4(3139) construct (Pep-C), exendin-4(139) or saline treat...

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ePoster

ea0070aep364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

In vitro and in vivo insulinotropic actions of magainin-AM1 on pancreatic beta cells and high fat fed mice

Abiodun Falobi Ayodele , Benjamin Falana Ayokunle , Abdel-Wahab Yasser HA , Flatt Peter R , Ojo Opeolu

Aim: Insulin-releasing effects and potential anti-diabetic actions of peptides isolated from the skin secretion of the African clawed frog, Xenopus amieti has been reported. However, peptides such as magainin-AM1 has not been previously studied for its ability to stimulate insulin secretion or promote glucose uptake. This study investigated insulin releasing effects as well as possible underlying mechanisms.Methods: Acute and chronic actions of ...

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Endocrine Abstracts

Stable analogues of the dual agonist dogfish glucagon show better therapeutic potential than exendin-4 in diet induced obese diabetic mice

In vitro and in vivo insulinotropic actions of magainin-AM1 on pancreatic beta cells and high fat fed mice

BiosciAbstracts